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The hyperphagia (and presumably the life-shortening) effect of the high BCAA turned out not to be due to increased BCAA levels themselves but to the imbalance between BCAAs and two other essential amino acids, threonine and tryptophan

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The available scientific evidences are all equivocal of the fact that synuclein fibrillation consists of two distinct steps a) Nucleation or initiation of fibrillation and b) elongation of fibrillation