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The FDA’s Designated High-Risk Groups The FDA's precautionary guidance names a specific list of vulnerable populations: Pregnant women and their developing fetuses Women planning to become pregnant Nursing mothers and their newborns Children under six, whose neurological systems are still developing People with pre-existing neurological conditions such as multiple sclerosis, Alzheimer's, or Parkinson's disease Individuals with impaired kidney function, since mercury excretion depends heavily on the kidneys Anyone with a known sensitivity or allergy to mercury or other amalgam components This guidance doesn't mean the FDA has proven harm in every case

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Another study did not justify any significant variation in the gut microbiota as a hallmark of ALS [176]