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Lipids are a high-impact energy source, affecting multiple biological processes, including the production and the storage of energy ( Disordered Lipid Profiles in Inflammatory Disease Numerous autoimmune diseases, including RA, psoriasis, and systemic lupus erythematosus, in which autoreactive CD4 + T cells participate in inflammatory tissue lesions share the accumulation of intracellular lipid droplets in such T cells ( Lipids accumulating in the synovial fluid of RA patients have been analyzed through liquid chromatography mass spectrometry, and more than 70 different components from different lipid classes have been detected ( The abnormal cholesterol profile in patients with preclinical RA and early RA is typical of metabolic syndrome: normal or mildly elevated total cholesterol, LDL cholesterol and triglycerides, associated with decreased HDL cholesterol levels (123)
